Services
Biochemical characterization and modification of Carbohydrate Active Enzymes (CAZymes), especially from (hyper)thermophilic microorganisms, for their exploitation in lignocellulosic biomasses and waste products hydrolysis and valorisation Biochemical characterization of protein molecules from different natural sources, including cold-adapted proteins from polar organisms. Biochemical characterization of innovative biocatalysts involved the carbon cycle for CO2 sequestration processes and the ...
Integration of membrane separation technology with bioprocesses
VTT bioreactor and bioprocess suite (VTT-Bioreactors) is composed of 60 bioreactors for parallel strain evaluations (0.2-2L), process optimization (2-20L) and process scale up (30-1200L). In addition the suite is equipped with over 30 on-line/at-line/off-line analytical instruments and has a large selection biomass separation and product purification systems. In additional there is a number of at-line analysis available (e.g. for label-free MS, HPLC, UPLC, CE, NMR) allowing analysis of wide range ...
DESIGN strategies to produce high levels of recombinant proteins and peptides in plants as bioreactors according to an in silico pipeline
The known structural features of the protein of interest (POI) are used for in silico modelling of the POI, and the choices of vector, target sequence, codon-usage, expression system and purification strategy are tailored to the required POI properties (e.g. stability, purity, or alleviation of allergenic/toxic features).
TESTING the different strategies by ...
- In silico modelling of recombinant proteins for optimization of their production in plants, including post-translational modifications and prediction of subcellular localisationAnalysis of:
- Folding: resistance to proteolytic digestion, disulfide bond pattern, solubility, binding to conformation-dependent antibodies.
- Oligomerization: velocity gradient centrifugation in different biochemical conditions; dynamic light scattering (DLS); SEC-MALS.
- Glycosylation: analysis with glycan-specific ...
Biomass harvesting deals with different technologies bought from manufacturers for biomass harvesting. The choice results from the preliminary technical study aiming at identifying relevant technologies for microalgae harvesting.As a reference, centrifuges are planned for the harvesting of the extensive production systems (10-20m3/j). They are completed with other state-of-the art or more innovative technologies with lower energy consumption.Biomass refinery and oil recovery mainly concerns ...
Screening of microbial strains for a given phenotype.
