Bioprocess optimization and scale up

VTT bioreactor and bioprocess suite (VTT-Bioreactors) is composed of 60 bioreactors for parallel strain evaluations (0.2-2L), process optimization (2-20L) and process scale up (30-1200L). In addition the suite is equipped with over 30 on-line/at-line/off-line analytical instruments and has a large selection biomass separation and product purification systems. In additional there is a number of at-line analysis available (e.g. for label-free MS, HPLC, UPLC, CE, NMR) allowing analysis of wide range of compounds to be used for off-line fermentation analysis (e.g. carbon metabolites, lipidomics, secondary metabolites, in vivo flux analysis). The main research areas supported by the infrastructure are high-throughput selection and testing of production strains, strain physiology as well as optimization, upscaling and piloting of microbial fermentations supported by bioinformatics and modelling tools.